Our msds database is an easy to use, do it yourself tool, and best of all. Hydroxypropyl cellulose 9004642 not listed lactose monohydrate 64044515 not listed propylene glycol 57556 2003380. The top countries of supplier is china, from which the percentage of hydroxypropyl cellulose price supply is 100% respectively. In this study, we explored the incorporation of hydroxypropyl cellulose hpc into a cnc film prepared by slow evaporation. The average number of substituted hydroxyl groups per glucose unit is referred to as the degree of substitution ds. It is used in the industry as an excipient and as an ophthalmic ingredient to treat dry eye disease and irritation caused by insufficient tears. Safety assessment of hydroxypropyl methylcellulose as a food ingredient article in food and chemical toxicology 4512.
An idealized structure for a portion of a hydroxypropyl cellulose molecule with a molar substitution ms of 3. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Hydroxypropyl methylcellulose, also known as hypropmellose or e464, is a semisynthetic form of cellulose used to make gel caps. Apr 01, 2019 2 a cellulose ether containing propylene glycol groups attached by an ether linkage having a hydroxypropoxy oc3h6oh content of 5 to 16 percent weight in weight ww on an anhydrous basis, i.
Proprietary ingredients indicated as hazardous have been assessed under standards for workplace safety. Do not use 2 doses at the same time or extra doses. Difference between methyl cellulose mc and hydroxypropyl methyl cellulose hpmc 1. Used as a emulsifier, stabilizer, whipping aid, protective colloid, film former or thickener in foods.
The information in this msds is written in good faith, but. Hydroxypropyl cellulose is a derivative of cellulose. Safety data sheet hydroxypropyl cellulose average mw 50,000. Use dry chemical powder, water spray fog, foam or co2.
This msds has been prepared by deep south chemical, inc. Hydroxypropyl cellulose 9004642 not listed not listed not listed polysorbate 80 9005656 not listed not listed not listed. Common name hydroxypropyl methylcellulose chemical name cellulose, 2hydroxypropyl methyl ether chemical structure cas number 9004653 proportion range more than 95% 4. Hazards identification classification of the substance or mixture ghs classification not classified as hazardous. Procedure transfer about 65 mg of hydroxypropyl cellulose, previously dried at 105 for 1 hour and accurately weighed, into the reaction flask. Material safety data sheet hydroxypropyl cellulose average. If irritation occurs or persists, get medical attention. It is used as an excipient, and topical ophthalmic protectant and lubricant.
American polymer standards corporation safety data sheet page 2 of 5 hydroxypropyl methylcellulose section 5. Safety data sheet hydroxypropyl cellulose average mw. Chemicalbook provide chemical industry users with hydroxypropyl cellulose boiling point melting point,hydroxypropyl cellulose density msds formula use. Identification 1 product identifier product name lhpc grade name lh11, lh21, lh22, lh31, lh32, lhb1 compendial name lowsubstituted hydroxypropyl cellulose nf substance name lowsubstituted hydroxypropyl cellulose 2 suppliers detail suppliers name shinetsu chemical co. Pfizer inc believes that the information contained in this material safety data sheet is accurate, and while it. Hydroxypropyl cellulose 9004642 tci america tci chemicals. Hydroxypropyl cellulose 9004642 buy and find out price and availability, msds, properties of tcis high quality specialty chemicals.
Hpmc has not been evaluated in any standard reproduction test. The common name for this form of the additive is low substituted hydroxypropyl cellulose. Material safety data sheet hydroxypropyl cellulose average mol. Add 10 ml of chromium trioxide solution 30 g in 70 ml. Chemistry of methocel cellulose ethers 1 the former official monograph name of hypromellose was hydroxypropyl methylcellulose or hpmc.
This product has a strong bad smell and irritation. Remove person to fresh air and get medical attention skin contact. Use dry chemical powder, water spray fog, foam or co2 unsuitable extinguishing media. Stage 6 harmonization official december 1, 2014 hydroxypropyl1. To support new drug applications in the united states, drug master files dmfs for these products are on file at the bureau of drugs of the u. A wide variety of hydroxypropyl cellulose price options are available to you, there are 742 suppliers who sells hydroxypropyl cellulose price on, mainly located in asia. Section 12 ecological information section disposal considerations dispose of in a manner consistent with federal, state, and local regulations. Safety data sheet sds applies only to the material as packaged. Iridescent cellulose nanocrystal films modified with.
Hydroxypropyl methyl 9004324 9099 cellulose sodium chloride nacl 7647145 1 10 3 hazards indentification emergency overview offwhite powder. See actual entry in rtecs for complete information. This product does not contain any chemicals known to state of california to cause cancer, birth defects, or any other reproductive harm. Identification of the substancemixture and of the companyundertaking 1. Hydroxypropyl methyl cellulose is easily soluble in cold water but difficult to be soluble in hot water. Propylene glycol ether of methylcellulose modified cellulose. The introduction of polymers into a chiral nematic cellulose nanocrystal cnc matrix allows for the tuning of optical and mechanical properties, enabling the development of responsive photonic materials. Hydroxypropylmethyl cellulose viscosity 2,6005,600 cp. Hpmc is hydrophilic water soluble, a biodegradable, and biocompatible polymer having a wide range of applications in drug delivery, dyes and paints, cosmetics, adhesives, coatings. Gonak hypromellose ophthalmic demulcent solution, 2. Suitability requirements transfer 1ml of this solution to a glass plate, and al resolution. Other companies are charging thousands of dollars to set up.
American polymer standards corporation safety data sheet. Extreme high moderate low santa cruz biotechnology. Hydroxypropyl cellulose 9004642 not listed not listed povidone 9003398 not listed not listed purified water 7732185 2317912 not listed additional information. Hydroxypropyl cellulose 9004642 not listed not listed additional information. Sigmaaldrich offers a number of hydroxypropyl cellulose products. Wear appropriate protective eyeglasses or chemical safety goggles as described by oshas eye and face protection regulations in 29 cfr 1910.
Cellulose, 2hydroxypropyl ether product safety read and understand the material safety data sheet msds before using this product. Hydroxypropyl methyl cellulose phthalate methods for cleaning up wear protective clothing as described in section 8 of this safety data sheet. Hydroxypropyl cellulose average mw 370,000, powder, 20. Hydroxypropyl cellulose cellulose, 2 hydroxypropyl ether is a derivative of cellulose with both water solubility and organic solubility. General properties of methocel cellulose ethers general properties common to the whole family of methocel cellulose ether products are listed below. Methocel k100m premium hydroxypropyl methylcellulose. Ginshicel mh product information methyl hydroxypropyl cellulose cas number. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. Safety data sheet hydroxypropyl cellulose average mw 50,000 1250,000 according to regulation ec no 19072006, annex ii, as amended.
Hydroxypropyl cellulose 9004642 not listed not listed opadry white not assigned not listed not listed polysorbate 80 9005656 not listed not listed additional information. Our team of scientists has experience in all areas of research including life science, material science, chemical synthesis, chromatography, analytical and many others. Sds of hydroxypropyl cellulose, safety data sheets, cas. Safety data sheet northwest missouri state university. Its chemically modified so that when it is heated, it becomes flexible but not flowable. Material safety data sheet hydroxypropyl methyl cellulose hpmc 1 company and product identification. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. The interaction of sodium dodecylsulfate with hydroxypropyl. The propylene oxide can be substituted on the cellulose through an ether linkage at the three reactive hydroxyls present on each anhydroglucose monomer unit of the cellulose chain. The toxicological properties of this material have not been fully investigated. Should you have any questions about the hydroxyethyl cellulose monograph, please contact dr. The hydroxyethyl cellulose monograph will be incorporated into usp nf and become official from aug. Hydroxypropyl cellulose sc252897 hazard alert code key. Section 12 ecological information section disposal considerations dispose of in a manner.
Show this safety data sheet to the doctor in attendance. The fibrous reaction product is purified and ground to a fine, uniform powder. Material safety data sheet the dow chemical company. Safety data sheet 2 hydroxypropyl acrylate date prepared. Cellulose hydroxypropyl methyl ether methocel 20231 hydroxypropyl methylcellulose culminal mhpc. List of abbreviations and acronyms that could be, but not necessarily are, used in this safety data sheet. Its semisynthetic in that it begins as cellulose, the carbohydrate building block of plant fiber. Hydroxypropyl cellulose hpc is a derivative of cellulose with both water solubility and organic solubility. In cosmetic and personal care product formulations it is used as a binder, emulsion stabilizer, film former, and a vis. Hydroxypropyl cellulose an overview sciencedirect topics. Hydroxypropyl methylcellulose is produced by treating heated cellulose fibers with a caustic solution which in turn is reacted with methyl chloride and propylene oxide yielding the propylmethyl ether of cellulose. Safety assessment of hydroxypropyl methylcellulose. Should you have any questions about the hydroxypropyl cellulose monograph, please contact dr.
Use of super fine grade hydroxypropyl cellulosehpcssl sfp in dry manufacturing. Some typical molecular weight values are given in table i. Klucel hydrooxypropylcellulose cs grade is a nonionic, watersoluble cellulose ether with a versatile combination of properties in personal care applications. Artificial tears may also be used for hypromeloose not listed in this medication guide.
Details of the supplier of the safety data sheet 2. Klucel hydroxypropylcellulose hpc is a nonionic watersoluble cellulose ether with a remarkable combination of properties. Cellulose derivatives such as methylcellulose, hydroxypropyl cellulose, and carboxymethyl cellulose cmc are being extensively used to produce films due to their suitable properties sanlaead et al. Safety data sheet hydroxypropyl methylcellulose date prepared. If you use hydroxypropyl cellulose on a regular basis, use a missed dose as soon as you think about it. Safety assessment of hydroxypropyl methylcellulose as a food. Firefighting measures suitable extinguishing media. Extreme high moderate low section 1 chemical product and company identification product name hydroxypropyl cellulose statement of hazardous nature not considered a hazardous substance according to osha 29 cfr 1910.
Hydroxypropyl cellulose 9004642 not listed dibasic calcium phosphate, dihydrate usp 7789777 not listed sodium starch glycolate 9063381 not listed. Immediately flush eyes with water for at least 15 minutes. Cellulose alone or in combination with other matrixes has been employed in food packaging applications. Sds of hydroxypropyl cellulose, safety data sheets, cas 9004642. Microcrystalline cellulose 9004346 2326749 not listed ingredient cas number eu einecselincs list ghs classification % hydrogenated castor oil 8001783 2322922 not listed hydroxypropyl methylcellulose 9004653 not listed not listed sodium starch glycolate 9063381 not listed not listed additional information. Klucel hydroxypropylcellulose hpc physical and chemical. Hypromellose msds pdf samples general properties of methocel cellulose ethers general properties common to the whole family of methocel cellulose ether products are listed below. Pfizer inc believes that the information contained in this material safety data sheet is accurate, and while it is provided in good faith, it. Therefore, take proper measures like informing the people in the. It combines organic solvent solubility, thermoplasticity, and surface activity with the aqueous thickening and stabilizing properties characteristic of other watersoluble cellulose polymers available from ashland. Feb 28, 2014 the hydroxypropyl cellulose monograph will be incorporated into and become official with the second supplement to usp 37nf 32. Hydroxypropylcellulose hpc in aqueous solution interacts with sodium dodecylsulfate sds to give micellelike sds clusters bound to the.
The product meets the monograph requirements of the national formulary nf, european pharmacopoeia ep, and japanese pharmacopoeia jp. Hydroxy propyl methyl cellulose cas no 9004653 material. Hydroxypropyl cellulose not listed as a carcinogen by acgih, iarc, ntp, or ca prop 65. Hydroxypropyl cellulose average mw 370,000, powder, 20 mesh particle size 99% through. Material safety data sheet hydroxypropyl cellulose sc252897 hazard alert code key. Clear up spills immediately and dispose of waste safely.
Wash the contaminated area with soap and water sufficiently. Hydroxypropyl methylcellulose hpmc belongs to the group of cellulose ethers in which hydroxyl groups have been substituted with one or more of the three hydroxyl groups present in the cellulose ring fig. Commission regulation eu no 2015830 of 28 may 2015. Safety data sheet hydroxypropylmethyl cellulose phthalate. Nlt 2 between isopropyl iodide and low the water to evaporate. Walocel mw 40000 pfv 50 methyl hydroxyethyl cellulose company identification the dow chemical company 2030 willard h.
Use water spray, alcoholresistant foam, dry chemical, or carbon dioxide. However, its gelling temperature in hot water is significantly higher than that of methyl cellulose mc. Hpc is an ether of cellulose in which some of the hydroxyl groups in the repeating glucose units have been hydroxypropylated forming och 2 chohch 3 groups using propylene oxide. How is this medicine hydroxypropyl cellulose best taken. Description, hydroxypropyl cellulose hpc is a derivative of cellulose being. One study in rats indicated there was an increase in fetal resorptions, gross and skeletal malformations after a 1 and 4% hpmc i. Collect powder using special dust vacuum cleaner with particle filter or carefully sweep into suitable waste disposal containers and seal securely.
1443 1184 687 126 424 1539 1121 1199 26 1422 423 31 612 691 1068 967 578 1246 1575 728 353 1596 170 1003 514 243 1267 1247 700 812 1463 96 11